Improved N-retention during L-Carnitine-Supplemented Total Parenteral Nutrition

Improved N-retention during L-carnitine-supplemented total parenteral nutrition.

The influence of intravenously administered L-carnitine on lipid- and nitrogen-metabolism was studied during total parenteral nutrition of piglets (mean weight 4077 g; n = 9). The infusion protocol was divided into three isocaloric and isonitrogenous 48-hr periods. Amino acids (3 g/kg day) were administered throughout all three periods: 140 cal/kg/day were given as nonprotein calories, consisti...

Hyperglycemia During Total Parenteral Nutrition

OBJECTIVE To determine the effect of total parenteral nutrition (TPN)-induced hyperglycemia on hospital outcome. RESEARCH DESIGN AND METHODS The study determined whether blood glucose values before, within 24 h, and during days 2-10 of TPN are predictive of hospital complications and mortality. RESULTS Subjects included a total of 276 patients receiving TPN for a mean duration of 15 +/- 24 ...

L-carnitine and cancer cachexia. II. Effects of lipid emulsion used in total parenteral nutrition on parameters of hemostasis and inflammatory state in L-carnitine deficiency in myocytes.

Cancer cachexia (CC), a progressive loss of body mass, leads to malnutrition and deficiencies of essential substances including polyunsaturated fatty acids (PUFAs) and L-carnitine (LC). The availability of these 2 compounds determines the rate of eicosanoid synthesis, which modulates inflammatory processes and hemostasis. We compared the effects of administration of emulsions containing long ch...

Total parenteral nutrition and sepsis.

In 1279 very premature or very low birthweight infants the use and duration of treatment with total parenteral nutrition were associated with short gestational age and low birth weight. Infants treated with total parenteral nutrition had a higher risk of sepsis usually caused by Staphylococcus epidermidis or Staphylococcus aureus.

Mechanisms of nutritional repletion during total parenteral nutrition.